Viral loads in clinical specimens and SARS manifestations.
Identifieur interne : 004F83 ( Main/Exploration ); précédent : 004F82; suivant : 004F84Viral loads in clinical specimens and SARS manifestations.
Auteurs : I F N. Hung [République populaire de Chine] ; V C C. Cheng ; A K L. Wu ; B S F. Tang ; K H Chan ; C M Chu ; M M L. Wong ; W T Hui ; L L M. Poon ; D M W. Tse ; K S Chan ; P C Y. Woo ; S K P. Lau ; J S M. Peiris ; K Y YuenSource :
- Emerging infectious diseases [ 1080-6040 ] ; 2004.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Charge virale, Femelle, Flambées de maladies, Fèces (virologie), Humains, Mâle, Partie nasale du pharynx (virologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (sang), Syndrome respiratoire aigu sévère (urine), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (isolement et purification).
- MESH :
- isolement et purification : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- sang : Syndrome respiratoire aigu sévère.
- virologie : Fèces, Partie nasale du pharynx, Syndrome respiratoire aigu sévère.
- urine : Adulte, Adulte d'âge moyen, Charge virale, Femelle, Flambées de maladies, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Disease Outbreaks, Feces (virology), Female, Humans, Male, Middle Aged, Nasopharynx (virology), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (urine), Severe Acute Respiratory Syndrome (virology), Viral Load.
- MESH :
- blood : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- physiopathology : Severe Acute Respiratory Syndrome.
- urine : Severe Acute Respiratory Syndrome.
- virology : Feces, Nasopharynx, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Disease Outbreaks, Female, Humans, Male, Middle Aged, Viral Load.
Abstract
A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.
DOI: 10.3201/eid1009.040058
PubMed: 15498155
Affiliations:
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Hung</name><affiliation wicri:level="1"><nlm:affiliation>Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Queen Mary Hospital at the University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V C C" last="Cheng">V C C. Cheng</name></author><author><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A K L" last="Wu">A K L. Wu</name></author><author><name sortKey="Tang, B S F" sort="Tang, B S F" uniqKey="Tang B" first="B S F" last="Tang">B S F. Tang</name></author><author><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name></author><author><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name></author><author><name sortKey="Wong, M M L" sort="Wong, M M L" uniqKey="Wong M" first="M M L" last="Wong">M M L. Wong</name></author><author><name sortKey="Hui, W T" sort="Hui, W T" uniqKey="Hui W" first="W T" last="Hui">W T Hui</name></author><author><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L L M" last="Poon">L L M. Poon</name></author><author><name sortKey="Tse, D M W" sort="Tse, D M W" uniqKey="Tse D" first="D M W" last="Tse">D M W. Tse</name></author><author><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name></author><author><name sortKey="Woo, P C Y" sort="Woo, P C Y" uniqKey="Woo P" first="P C Y" last="Woo">P C Y. Woo</name></author><author><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="ISSN">1080-6040</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Outbreaks</term><term>Feces (virology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nasopharynx (virology)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (physiopathology)</term><term>Severe Acute Respiratory Syndrome (urine)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Femelle</term><term>Flambées de maladies</term><term>Fèces (virologie)</term><term>Humains</term><term>Mâle</term><term>Partie nasale du pharynx (virologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Syndrome respiratoire aigu sévère (physiopathologie)</term><term>Syndrome respiratoire aigu sévère (sang)</term><term>Syndrome respiratoire aigu sévère (urine)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (isolement et purification)</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fèces</term><term>Partie nasale du pharynx</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Feces</term><term>Nasopharynx</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Charge virale</term><term>Femelle</term><term>Flambées de maladies</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Syndrome respiratoire aigu sévère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A retrospective viral load study was performed on clinical specimens from 154 patients with laboratory-confirmed severe acute respiratory syndrome (SARS); the specimens were prospectively collected during patients' illness. Viral load in nasopharyngeal aspirates (n = 142) from day 10 to day 15 after onset of symptoms was associated with oxygen desaturation, mechanical ventilation, diarrhea, hepatic dysfunction, and death. Serum viral load (n = 53) was associated with oxygen desaturation, mechanical ventilation, and death. Stool viral load (n = 94) was associated with diarrhea, and urine viral load (n = 111) was associated with abnormal urinalysis results. Viral replications at different sites are important in the pathogenesis of clinical and laboratory abnormalities of SARS.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chan, K H" sort="Chan, K H" uniqKey="Chan K" first="K H" last="Chan">K H Chan</name><name sortKey="Chan, K S" sort="Chan, K S" uniqKey="Chan K" first="K S" last="Chan">K S Chan</name><name sortKey="Cheng, V C C" sort="Cheng, V C C" uniqKey="Cheng V" first="V C C" last="Cheng">V C C. Cheng</name><name sortKey="Chu, C M" sort="Chu, C M" uniqKey="Chu C" first="C M" last="Chu">C M Chu</name><name sortKey="Hui, W T" sort="Hui, W T" uniqKey="Hui W" first="W T" last="Hui">W T Hui</name><name sortKey="Lau, S K P" sort="Lau, S K P" uniqKey="Lau S" first="S K P" last="Lau">S K P. Lau</name><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name><name sortKey="Poon, L L M" sort="Poon, L L M" uniqKey="Poon L" first="L L M" last="Poon">L L M. Poon</name><name sortKey="Tang, B S F" sort="Tang, B S F" uniqKey="Tang B" first="B S F" last="Tang">B S F. Tang</name><name sortKey="Tse, D M W" sort="Tse, D M W" uniqKey="Tse D" first="D M W" last="Tse">D M W. Tse</name><name sortKey="Wong, M M L" sort="Wong, M M L" uniqKey="Wong M" first="M M L" last="Wong">M M L. Wong</name><name sortKey="Woo, P C Y" sort="Woo, P C Y" uniqKey="Woo P" first="P C Y" last="Woo">P C Y. Woo</name><name sortKey="Wu, A K L" sort="Wu, A K L" uniqKey="Wu A" first="A K L" last="Wu">A K L. Wu</name><name sortKey="Yuen, K Y" sort="Yuen, K Y" uniqKey="Yuen K" first="K Y" last="Yuen">K Y Yuen</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Hung, I F N" sort="Hung, I F N" uniqKey="Hung I" first="I F N" last="Hung">I F N. Hung</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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